Seagen
Scientist Conjugation Process Development
Technical Operations & Process Sciences - Bothell, United States
Description
Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!
Summary:
The Conjugation Process Development group is seeking a Scientist with a strong background in process engineering to assist in the development of conjugation processes for antibody-drug conjugates (ADCs). The Scientist provides technical and scientific leadership as subject matter expert (SME) relating to technology transfers, manufacturing processes, technical troubleshooting, process monitoring, and process optimization, supporting internal development and CMO’s to introduce robust manufacturing processes. The ideal candidate has a proven track record contributing to process engineering projects, displaying creativity, technical expertise, and cross-functional collaboration.
Principal Responsibilities:
- Provide technical and team leadership for conjugation process engineering tasks and initiatives across Seagen manufacturing sites
- Serves as primary conjugation SME for pre-IND and/or late-stage programs
- Identifies areas for process improvement and technology development and proposes solutions
- Demonstrates growing knowledge of other functional areas within Process Sciences
- Provide technical expertise in oversight of clinical and registrational manufacturing activities
- Prepare lab and pilot scale antibody drug conjugates
- Independently lead process development activities for antibody drug conjugate programs
- May support validation activities
- May plan and support process characterization activities
- Organize and present clear presentations of work at departmental and project meetings. May present at national/international forums
- May represent department on inter-departmental teams
- Author and review technical reports, manufacturing documents, regulatory submissions, and publications
- May supervise direct reports. Motivates and supports the career development and technical growth of direct reports. Regularly meets with, sets clear goals and expectations, and provides timely feedback to direct reports
Qualifications:
- Degree in chemical engineering, chemistry, biochemistry or related field B.S. and 10+ years; M.S. and 8+ years; Ph.D. and 0-3 years (may include post-doctoral experience)
- Experience with GMP manufacturing
- Familiarity with CMC team function
- Experience with technology transfer to manufacturing
- Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)
- Statistical software use, such as JMP
- Direct experience with antibody or protein modification
- Proficiency with tangential flow filtration
As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.
The hiring pay range for this position is $106,000 to $138,000 per year based on skills, education and experience relevant to the role. Other components of total compensation include a competitive equity grant at the time of hire (with additional annual grants, and grants upon promotion when applicable), and an annual bonus.
Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.
Apply:
Seagen
Seagen is an Equal Opportunity Employer
Submitted: 09/28/2023
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